Vietnamese biologists invent genetic-mutation detection technology
(Record.vn) After two years of research, the Molecular Biology Department of the Central Military Hospital 108 has mastered the technology to detect genetic mutation with high reliability.
biology testing room (vast.ac.vn)
Molecular biologists have found it difficult to discover mutations that may cause cancer because they occur only in malignant cells, such as EGFR, Kras, and PIK3CA in lung and colorectal cancer, and FLT3 , NPM1 and JAK2 in leukemia.
In addition, the current method of taking specimens do not ensure high accuracy as malignant cells may not appear in the samples.
As such, scientists have to find mutation detection methods with high reliability which can discover such mutations or those that only circulate in peripheral blood.
To date, international associations including the European Society for Medical Oncology, the American Society of Clinical Oncology, insurers and the Ministry of Health of Vietnam have not set up any standard method to discover the mutations that may cause cancer.
Laboratories and hospitals in the world use many different methods to detect mutations and different procedures to collect specimens.
Sanger sequencing is the lowest-cost and easiest method, but it has the lowest sensitivity. It can only discover mutations when the number of mutated cells is higher than 20 percent of total cells.
PCR, or Polymerase Chain Reaction, is a method based on the Taqman probe. If Taqman is integrated with Amplification Refractory Mutation System (ARMS), it can discover mutations when malignant cells account for more than 1 percent of total cells.
However, as Vietnam cannot create Taqman probes in accordance with ARMS, all the laboratories using PCR have to import compatible testing kits.
As a result, it is very costly to discover EGFR, Kras and PIK3CA mutations. On average, every patient has to pay VND8 million for every test.
The Bidirectional allele specific PCR with ARMS technology is also an advanced method which high sensitivity. However, the method is costly and cannot be applied on a large scale because the cost is too high for most Vietnamese.
The technology invented by the Central Military Hospital 108 has important significance. With its technology and testing kit, the test costs only VND2.5 million.
According to Ngo Tat Trung and Le Huu Song from the hospital, the testing kit, priced at just one-third of the foreign-made kit, has been recognized by EMQN as meeting safety and accuracy standards for cancer diagnoses.
The Central Military Hospital 108 is considered as one of the most famous hospitals in Vietnam. It is the first hospital in Vietnam that carried out organ transplants (kidney, liver). It is also famous for surgery.
Source: vietnamnet.vn
VIETNAM BOOK OF RECORDS- VIETKINGS
(Records.vn) The invention of automated teller machine (ATM), nano technology which helps eliminate toxicity from water or fuel saver for motorbikes have all brought high income and helped humans save energy are the important distribution of Vietnamese people for the scientific society as well as the people in the world.
(Records.vn) The invention of automated teller machine (ATM), nano technology which helps eliminate toxicity from water or fuel saver for motorbikes have all brought high income and helped humans save energy are the important distribution of Vietnamese people for the scientific society as well as the people in the world.
(Records.vn) Areas that are prone to flood when the heavy rain come could have a solution to all their problems with this magic type of concrete.
(Vietkings) With many urbanites worrying about the use of growth chemicals in vegetables, services providing small hanging gardens and care for fresh vegetables grown at home are prospering.
(Vietkings) UCLA bioengineers develop platform that offers personalized approach to treatment.
(Records.vn) Researchers at the UPM are testing new wearable sensor networks and mobile phone applications to monitor and manage patients with Parkinson's disease.
(Records) Cardiff Skate Company recently invented Walk Wing, with strap-on skates of the regular shoes.
(Vietkings) – Begin the career at plastic industry, Mr. Pham Hoang Thang started researching and creating the sowing machine made from plastic since the year 2000 and applied widely in agriculture and accepted by the farmers in the whole country. From this archievement, in 2003, Thang continued to create the solution ejecting device that help the farmers in ejecting the repellent on the paddy and can get rid off the toxicity of this work.
(Records) Animals at specialist charity will undergo evaluation at Milton Keynes hospital after proving 93% effective in detecting odour of prostate tumours
(Records) The Ho Chi Minh municipal authorities will develop high-tech agriculture in an effort to boost agricultural production despite shrinking farmland
(Records) Intel Products Vietnam heralded a grand opening of the largest solar power station in Vietnam at the Saigon High-Tech Park on April 23.
(Records) Marines are known for risking their lives on the battlefield, but more and more, robot technology is helping to avoid those dangers and save lives.
(Records) Vietnam has become the world's 10th country to successfully applying nanotechnology to produce Nano Curcumin - a substance that can help cure cancer, announced the Vietnam Academy of Science and Technology.
(Records) BEAVERTON, Oregon – Matthew Walzer, 19, said putting on shoes was nearly impossible. He has cerebral palsy, and often had to ask his parents to help him get dressed.
(Records) DIABETES could be cured by simply taking a pill that “rewires” the body, researchers have claimed.
Headquarter: 148-150 Hong Ha, 9 Ward, Phu Nhuan District, Ho Chi Minh City
Tel: (+84)8 384 78965 - Fax: (+84)8 384 78904 - Hotline: +(84) 903 727 624; +(84) 01288 617 009
Email: noidungkyluc@gmail.com